Psoriasis und lr
N Engl J Med ; Psoriasis is important to the clinician because it is common and has treatment implications beyond the care of skin lesions. It is important to the physician-scientist because it serves as a model for studies of mechanisms of chronic inflammation. It is important to the clinical-trial investigator because it is Psoriasis und lr a first-choice disease indication for proof-of-principle studies of new pathogenesis-based therapeutic strategies.
In recent years, substantial advances have been made in elucidating the molecular mechanisms click psoriasis. However, major issues remain unresolved, including the primary nature of the disease as an epithelial or immunologic disorder, the autoimmune cause of the inflammatory Psoriasis und lr, the relevance of cutaneous versus systemic factors, and the role of genetic versus environmental influences on disease initiation, progression, and response to therapy.
This review summarizes recent progress in our understanding of the molecular and immunologic basis of psoriasis and shows how improved insight into disease mechanisms has already resulted in tangible benefits for patients, including the introduction of new targeted therapies.
In addition, patients with psoriasis, like those with other major medical disorders, have reduced levels of employment Psoriasis und lr income as well as a decreased quality of life.
The disease Psoriasis und lr usually manifested as raised, well-demarcated, erythematous oval plaques with adherent silvery scales Figure 1 Figure 1 Clinical and Histologic Features of Psoriasis.
Erythematous, scaly, sharply demarcated plaques in different sizes and shapes are hallmarks of psoriasis. Although there are predilection sites such as the elbows, knees, and the sacral region, lesions may cover the entirety of the skin Panels A and C. Concurrent psoriatic arthritis often affects multiple aspects of the interphalangeal joints of the Psoriasis und lr Panel B. The nails are frequently affected, with nail dystrophy and psoriatic lesions of the nail bed.
The Psoriasis und lr picture Panel D, hematoxylin and eosin is characterized by thickening of the epidermis, parakeratosis, elongated rete ridges, and a mixed cellular infiltrate. Clinical photographs courtesy of St. The scales are a result Psoriasis und lr a hyperproliferative epidermis with premature maturation of keratinocytes and incomplete cornification with retention of nuclei in the stratum corneum parakeratosis.
The mitotic rate of the basal keratinocytes is increased as compared with that in normal skin. As a result, the epidermis is thickened acanthosiswith elongated rete ridges; in combination with the dermal inflammatory infiltrate, this contributes to the overall thickness of lesions, which can vary between thick- and thin-plaque psoriasis and has source proposed as a distinctive trait. The redness of the Psoriasis und lr is due to increased numbers of tortuous capillaries that reach the skin surface through a markedly thinned epithelium.
Population studies clearly indicate that the incidence of psoriasis is greater among first-degree and second-degree relatives of patients than among the general population.
The mode of inheritance of psoriasis is complex. Classic genomewide linkage analysis has identified at least nine chromosomal loci Psoriasis und lr statistically significant linkage to psoriasis; these loci are called psoriasis susceptibility 1 through 9 PSORS1 through PSORS 9 Table 1 Table 1 Major Psoriatic Gene Variants and Loci with Independent Replication.
PSORS1 is located within the major histocompatibility complex MHC on chromosome 6p, spanning an approximate kb segment within the class I telomeric region of HLA-B. Three genes within the region Psoriasis und lr been the major focus of Psoriasis und lr click here of the strong association of polymorphic coding-sequence variants with psoriasis vulgaris.
CCHCR1 associated variant, WWCC encodes the coiled-coil, x-helical rod protein 1, a ubiquitously expressed protein that is overexpressed in psoriatic epidermis. Absolute identification of the causative gene at this locus has been challenging because of the extensive linkage disequilibrium i.
Current data suggest that HLA-Cw6 is the susceptibility allele within PSORS1 9,30 ; however, no disease-specific mutations have been identified, and variants in regulatory sequences potentially affecting several downstream Psoriasis und lr cannot be ruled out.
HLA-C is an interesting candidate gene, since it might be involved in immune responses at the levels of both antigen presentation and Psoriasis und lr killer—cell Psoriasis und lr. Studies have clearly shown that the clinical variants of psoriasis are genetically heterogeneous at least at the level of PSORS1.
Thus, guttate psoriasis, an acute-onset form usually occurring in adolescents, is strongly Psoriasis und lr with PSORS131 whereas late-onset cases of psoriasis vulgaris cases in persons over 50 years of age and palmoplantar pustulosis are not associated with PSORS1. Genomewide association scans have identified variants in the gene read article the interleukin receptor IL23R and in the untranslated region of the interleukinB IL12B p4 0 gene as Psoriasis und lr indicators of psoriasis risk.
The results of several genomewide association scans of psoriasis have been reported. In addition Psoriasis und lr the IL23R and IL12B variants, these Psoriasis und lr include zinc-finger protein ZNFwhich is also called ring-finger protein RNF ; this gene is abundantly expressed in skin.
Psoriasis und lr addition to comprehensive analysis of gene variants, whole-genome analysis of the psoriasis-specific transcriptome has provided important insights into disease-relevant cells and pathways. An additional dimension for the regulation of gene-expression visit web page Psoriasis und lr inflammatory processes is potential control through microRNAs miRNAs.
Early studies suggest the possible involvement of miRNAs in psoriasis — for example, through interference with key inflammatory checkpoints. These recent studies have Psoriasis und lr progress Psoriasis und lr obtaining a whole-genome perspective on psoriasis and have provided robust and reproducible data sets. These studies provide support for an important role of the immune system in the disease process.
Studies in the s showed the presence of substantial numbers of immune cells in patients with psoriasis, suggesting Psoriasis und lr possible pathogenic role. This evidence includes the presence of increased numbers of immune cells especially dendritic cells and T cells in psoriatic lesions, 39,40 the appearance of clonal T cells in Psoriasis und lr over time, 41 the functional role of T cells and cytokines in human models of psoriasis, 42 the therapeutic activity of drugs targeting the immune system, 43,44 the findings that psoriasis may be cured in patients who have undergone bone marrow transplantation Psoriasis und lr that psoriasis can be transferred from transplant donor to recipient, 45,46 and the observation that top hits in whole-genome scans of genes and messenger RNA are immune-related.
Thus, psoriatic lesions probably evolve as an interplay between cells and mediators of the immune system — specifically, its innate and adaptive function — and skin epithelium and connective Psoriasis und lr Figure 2 Figure 2 Key Cells and Mediators in the Transition from Innate to Adaptive Immunity in Psoriasis und lr. Activated dendritic cells present antigens and secrete mediators such as interleukin and interleukin, leading to the differentiation of type 17 and type 1 helper T cells Th17 and Th1.
T cells, Psoriasis und lr turn, secrete mediators e. These soluble mediators feed back into the proinflammatory disease cycle and shape the inflammatory infiltrate. An interplay between environmental and genetic factors sets the scene for disease-initiating events. Activated myeloid dendritic cells migrate into draining lymph nodes and induce the differentiation of naive T cells into effector cells such as type 17 helper T cells Th17 or type 17 cytotoxic T cells Tc17 and type 1 helper T cells Psoriasis und lr or type 1 cytotoxic T cells Tc1.
Effector cells recirculate and slow down in skin capillaries in the presence of selectin-guided and integrin-guided receptor—ligand interactions. Immune cells expressing the chemokine receptors CCR6, CCR4, and CXCR3 emigrate into skin tissue Psoriasis und lr chemokine gradients.
These mediators act on keratinocytes, leading to the activation, Psoriasis und lr, and production of antimicrobial peptides e. Dendritic cells and T cells form perivascular clusters and lymphoidlike structures around blood vessels in the presence of chemokines such as CCL19 produced by macrophages. Unconventional T cells, including natural killer T cells, contribute to the disease process.
Feedback loops involving keratinocytes, fibroblasts, and endothelial cells contribute to tissue reorganization with endothelial-cell activation and proliferation and deposition of extracellular matrix.
Neutrophils in the epidermis are attracted by chemokines, including interleukin-8 CXCL8 and CXCL1. The innate immune system provides an early-response mechanism against harm to the host through recognition by preformed, nonspecific effectors.
There is evidence of dysregulation of the innate immune system in psoriasis. Psoriasis und lr addition to their antimicrobial activity, antimicrobial peptides can also have a chemotactic function and shape immune-cell function, including that of dendritic cells and T cells. They are Psoriasis und lr to key dendritic cell—derived and T-cell—derived cytokines, including interferons, TNF, interleukin, and the interleukin family of cytokines, and in turn they will produce proinflammatory cytokines e.
Thus, a rich interface between effectors of the innate and adaptive immune system shapes the psoriatic inflammatory process. Dendritic cells are key sentinels of the immune system, bridging the gap between innate and adaptive immunity. Myeloid dermal dendritic cells are increased in psoriatic lesions and induce autoproliferation of T cells as well Psoriasis und lr production of type 1 helper T cell Th1 cytokines.
A key question concerns the autoimmune nature of psoriasis and the contribution of autoreactive Psoriasis und lr cells to the disease process. Currently available data do not support the notion that psoriasis is a bona fide autoimmune disease.
Psoriasis is probably best placed within Psoriasis und lr spectrum of autoimmune-related diseases characterized by chronic inflammation in the absence of known infectious agents or antigens. The transport of T cells from the dermis into the epidermis is a key event in psoriasis. Psoriasis und lr of this interaction inhibits the development of psoriasis in clinically relevant models. This cell type is specialized Psoriasis und lr immunosurveillance ob möglich ist, eine Tätowierung Psoriasis zu Psoriasis und lr, and it also secretes interleukin, a key cytokine linking adaptive immune effectors and epithelial dysregulation in psoriasis.
Interleukin induces proliferation of keratinocytes and production of antimicrobial peptides as well as chemokines. Thus, complex and in part redundant psoriasis-relevant cytokines converge on key well-known intracellular checkpoints that are common to many chronic inflammatory conditions. During tissue homeostasis, proinflammatory states are balanced through counterregulatory mechanisms.
Although studies have indicated that the Psoriasis und lr of regulatory T Treg cells are not altered in lesional psoriatic skin, there seems to be a defect in their overall suppressive activity. Early clinical studies showed that interleukin has moderate therapeutic Psoriasis und lr, an observation that has not been confirmed in larger, controlled trials.
Evidence of a role of endothelial cells in psoriasis includes the increased expression of vascular endothelial growth factor VEGF75 psoriasiform inflammation in mouse models with transgenic overexpression of VEGF in Psoriasis und lr epidermis, the association of psoriasis with VEGF gene variants, 76 and the efficacy of drugs targeting angiogenesis in animal models.
VEGF and angiopoietins are some of the factors believed to be responsible for these vascular changes in psoriasis. With the exception of a few sporadic cases in primates, psoriasis is unique to humans. Thus, the available nonhuman models of psoriasis usually provide only an approximation of the disease.
The three den Psoriasis Händen, tun auf die types of Psoriasis und lr vivo animal models usually rely on mice as hosts and are based on the following experimental settings: Spontaneous mutation in mouse models has resulted Psoriasis und lr inflammatory and scaly skin phenotypes, but these models usually represent only a limited set of psoriatic features.
There are two broad categories of genetically engineered mice: In most cases, genetic modification is targeted to the epidermis through specific promoters.
These models test the hypothesis that overexpression of a given cytokine, growth factor, adhesion molecule, or signaling element contributes to an inflammatory skin disease. This model recapitulated Psoriasis und lr of the known critical checkpoints in the pathogenesis of psoriasis, including activation of plasmacytoid dendritic cells and dependence on Th17 cells.
These differences include the extent of interfollicular epidermis, the thickness of the epidermis, the density of hair follicles, the differentiation program of keratinocytes, and the presence of mouse versus human immune cells. In an attempt to overcome these problems and to develop humanized mouse models, the transplantation of skin from patients with psoriasis into immunosuppressed mice has been a promising area of investigation. Transplants can be obtained from either symptomless nonlesional or lesional skin of patients with psoriasis.
Such xenotransplantation models allows studies of the development of psoriasis and of established psoriasis. Thus, these models can be used Psoriasis und lr address two seminal questions in psoriasis research Figure 3: What are disease-initiating events? What are disease-maintaining events? These insights ultimately have led to answers related to the prevention and treatment of psoriasis. The shared conditions include the metabolic syndrome, depression, and cancer.
If confirmed, these findings would have major implications for future preventive and therapeutic strategies. Classic systemic treatments for psoriasis have not fully met the needs of patients. The proof of principle of pathogenesis-based therapy in dermatology has created a multitude of opportunities for the development of new drugs that are currently moving through the phases of clinical development.
Biologic therapies in psoriasis are Psoriasis und lr effective and Psoriasis und lr be classified according to their mechanism of action. Targeted biologic therapies that have been approved Psoriasis und lr marketing or for which phase 3 clinical data have been published are shown. The two major therapeutic classes are T-cell—targeted therapies alefacept and efalizumab and anticytokine therapies anti—tumor necrosis factor [TNF] therapies: Efalizumab which has been withdrawn from the market is a chimeric monoclonal anti-CD11a antibody.
It blocks the interaction of CD11a lymphocyte-function—associated antigen [LFA] 1 [LFA-1] with intercellular adhesion Psoriasis und lr 1 ICAM-1leading to a disruption of the interaction between dendritic cells and T cells at tissue sites and in lymph nodes as well as blocking of immune-cell binding to blood vessels.
Alefacept is a human LFA 3 LFA-3 Fc fusion protein that blocks the interaction between CD2 on T cells and LFA-3 on antigen-presenting cells. It also induces antibody-dependent cytotoxicity in T cells bound to alefacept. Anti-TNF strategies have three variants: Finally, blocking of interleukin and interleukin is achieved by means of antibodies targeting the common p40 chain of these cytokines.
CD denotes Psoriasis und lr designation, and FcR Fc receptor. T-cell—targeted biologic agents such as alefacept and efalizumab which has been withdrawn from the market have validated the concept of a role of T cells in established disease.
Anticytokine therapies have been developed through advances in anti-TNF therapy in chronic inflammatory diseases, including psoriasis. However, a multitude of issues, including long-term efficacy, relapse after drug withdrawal, safety, and costs, are driving the search for new and better therapies.
The latest addition to the anticytokine drugs are antibodies targeted at the interleukin and interleukin family of heterodimeric cytokines that share a common p40 chain. Randomized, controlled studies have shown the efficacy and short-term safety of anti-p40 antibodies in psoriasis and psoriatic arthritis. Current biologic therapies are well tolerated overall, and some are more effective than conventional systemic therapies. The evolution of a psoriatic lesion is based on a complex interplay between environmental and genetic factors that sets the scene for disease-initiating events.
A cascade Psoriasis und lr events leads to activation of dendritic cells and, in turn, the generation of effector T cells that emigrate to and reside in skin tissue. Cross-talk between epithelial cells and immune cells shapes and maintains the inflammatory milieu. Research in the Psoriasis und lr decade has identified many of the checkpoints governing these processes and has lead to the Psoriasis und lr of new, highly effective targeted therapies.
Although this progress is remarkable, there are still many unknowns, especially in the area of disease prevention and the development of drugs with appropriate long-term risk—benefit and cost profiles.
Future research will need to tackle these challenges in order to establish therapeutic and preventive approaches that ultimately lead to improved outcomes for patients. Barker reports receiving grant support from Schering-Plough and Abbott, consulting fees from Abbott and Wyeth, and lecture fees from Schering-Plough, Janssen-Cilag, Abbott, and Wyeth; and Dr. Nestle, receiving consulting fees from Galderma, Boehringer Ingelheim, Abbott, Janssen-Cilag, Merck Serono, and Wyeth and lecture fees from Abbott, Janssen-Cilag, and Wyeth.
We thank Paola Di Meglio, Antonella Di Cesare, Niwa Ali, Deepika Kassen, Gayathri Perera, and Eduardo Calonje for help with earlier versions of the figures and Brian Nickoloff, Richard Trembath, Francesca Capon, and Psoriasis und lr Hayday for helpful discussions.
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Masaru Honma, Takashi Shibuya, Takeshi Iwasaki, Shin Iinuma, Noriyoshi Psoriasis und lr, Mari Psoriasis und lr, Masako Minami-Hori, Akemi Ishida-Yamamoto.
A close correlation with bilateral diagonal earlobe creases. Rongkun Dou, Zongying Liu, Xue Yuan, Danzhou Xiangfei, Ruixue Bai, Zhenfei Bi, Piao Yang, Yalan Psoriasis und lr, Yinsong Dong, Wei Su, Diqiang Li, Canquan Mao, Andrzej T. Sreya Bagchi, Ying He, Hong Zhang, Liang Cao, Ildiko Psoriasis und lr Rhijn, D.
Branch Moody, Johann E. Journal of Clinical Investigation Eric Helmer, Mark Watling, Emma Jones, Dominique Tytgat, Mark Jones, Rodger Allen, Andrew Payne, Annelize Koch, Eugene Healy. European Journal of Clinical Pharmacology Hsien-Yi Chiu, I-Ting Wang, Weng-Foung Huang, Yi-Wen Tsai, Ming-Neng Shiu, Tsen-Fang Tsai. A nationwide population-based matched cohort study. Journal of the American Academy of Dermatology Charlie Bridgewood, Martin Stacey, Adewonuola Alase, Dimitris Lagos, Anne Graham, Miriam Wittmann.
Journal of Allergy and Clinical Immunology JAAD Case Psoriasis und lr 3: Lin Sun, Zeyu Liu, Lun Wang, Dongmei Cun, Henry H. Tong, Ru Yan, Xin Chen, Ruibing Wang, Ying Zheng. Psoriasis und lr of Controlled Release Host defense antimicrobial peptides and proteins in human skin diseases.
Indhumathi, Medha Rajappa, Laxmisha Chandrashekar, P. Annunziata Dattola, Simone Altobelli, Psoriasis und lr Marsico, Domenico Plastina, Steven P. Nistico, Armando Cavallo, Roberto Floris, Luca Bianchi, Manlio Guazzaroni.
Photomedicine and Laser Surgery. Line Raaby, Cecilia Rosada, Ane Langkilde, Kristina Lystlund Lauridsen, Hanne Vinter, Pernille Ommen, Rasmus Boye Kjellerup, Claus Johansen, Lars Iversen. New England Journal of Medicine Michael Doumas, Niki Katsiki, Vasilios Papademetriou. Two Sides of the Same Coin?. Angiology 30 Mio Nakamura, Kristina Lee, Rasnik Singh, Tian Hao Zhu, Benjamin Farahnik, Michael Abrouk, John Koo, Tina Bhutani. Journal of Dermatological Treatment Line Raaby, Ole Ahlehoff, Annette de Thurah.
Theresa Stjernholm, Pernille Ommen, Ane Langkilde, Claus Johansen, Lars Iversen, Cecilia Rosada, Karin Stenderup. Meng Jiang, Weiyuan Ma, Yumei Gao, Kun Jia, Yan Zhang, Haidong Liu, Qing Sun. British Journal of Dermatology Daniyal Aleem, Hassaan Tohid.
A Mechanistic Approach of Depression and Psoriasis. Mohan, Huayi Zhang, Lei Bao, Benjamin Many, Lawrence S. Sunil Dogra, Shraddha Uprety, Swaroop Hassan Suresh. Expert Opinion on Biological Therapy Expert Opinion on Drug Safety Chunying Xiao, Zhenlai Zhu, Shuhong Sun, Jixin Gao, Meng Fu, Yufeng Liu, Gang Wang, Xu Yao, Wei Li. Mehta, Alexis Ogdie, Abby S. Van Voorhees, Joel M. Andrew Blauvelt, Kim A. Griffiths, Bruce Randazzo, Yasmine Wasfi, Yaung-Kaung Shen, Shu Li, Alexa B.
Results from the phase III, double-blinded, placebo- and active comparator—controlled VOYAGE 1 trial. Radomir Reszke, Jacek C Szepietowski. Hung-Pin Tu, Chu-Ling Yu, Cheng-Che E.
Shin Morizane, Kazuko Mizuno, Tetsuya Takiguchi, Saeko Sugimoto, Keiji Iwatsuki. Elien Van Nuffel, Anja Schmitt, Inna S. Afonina, Klaus Schulze-Osthoff, Rudi Beyaert, Stephan Hailfinger.
Ying Xiong, Hongxiao Chen, Liqian Liu, Leihong Psoriasis und lr, Zongshan Wang, Fujun Tian, Yongliang Zhao.
A Potential Role in Psoriasis. DNA and Cell Biology Melodie Young, Lakshi Aldredge, Patti Parker. Journal of the American Association of Nurse Practitioners Tetsuya Honda, Osamu Yamamoto, Yu Sawada, Gyohei Egawa, Akihiko Kitoh, Atsushi Otsuka, Teruki Dainichi, Saeko Nakajima, Yoshiki Miyachi, Kenji Kabashima.
Journal of Allergy and Clinical Immunology. Vidal Delgado-Rizo, Marco A. Frontiers in Immunology 8. Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide. Cheng Feng, Ming Bai, Nan-Ze Yu, Xiao-Jun Wang, Zeng Liu. Journal of Cellular and Molecular Medicine Tae-Hoon Shin, Hyung-Sik Kim, Soon Choi, Kyung-Sun Psoriasis und lr. Clinical Potential and Mode of Action.
International Journal of Molecular Sciences Shanzao Chen, Kesheng Han, Hu Li, Juren Cen, Yanfang Yang, Hezhen Wu, Qun Wei. Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in Mice. Journal of Agricultural and Food Chemistry Psoriasis und lr Journal of the European Academy of Dermatology and Venereology. Xiaoyun Yu, Jingang An, Yunhui Hua, Zihai Li, Ning Yan, Weixin Fan, Chuan Su.
Pathology - Visit web page and Practice Alexandros Mitsios, Athanasios Arampatzioglou, Stella Arelaki, Ioannis Psoriasis und lr, Konstantinos Ritis.
Unraveling the Dark Side of Old Diseases through Neutrophils. Frontiers in Immunology 7. Jean Christopher Chamcheu, Vaqar M. Adhami, Stephane Esnault, Mario Sechi, Imtiaz A. Dodwad, Maria-Ines Chaves-Rodriquez, B. Jack Longley, Gary Grundlagen Psoriasis. Shinnosuke Muramatsu, Ryoji Kubo, Emi Nishida, Akimichi Morita. Reference Module in Life Sciences. Toshiya Takahashi, Richard L.
Cognetta, Qing-Xiang Amy Sang. Medicinal Research Reviews Ahmed Nadeem, Naif O. Sebastian Volc, Kamran Ghoreschi, Hui Shen. Ying Wang, Lili Wang, Yanchao Shi, Feifei Wang, Haoyu Yang, Shuo Han, Yanping Bai. Immunology Letters Correlation with disease activity and severity. The Egyptian Psoriasis und lr The Paradigm of Cytokine-Mediated Cardiovascular Metabolic Disease in Psoriasis.
Ole-Jan Iversen, Hilde Lysvand, Geir Slupphaug. Clinical Immunology Hanne Vinter, Ane Langkilde, Vijole Ottosson, Alexander Espinosa, Marie Wahren-Herlenius, Psoriasis und lr Raaby, Claus Johansen, Lars Iversen. Bioactive Polyphenols for Diabetes and Inflammation in Psoriasis Disease. Studies in Natural Products Chemistry, Surgical Denervation in the Imiquimod-Induced Psoriasiform Mouse Model. Click at this page, Sioh Yang Tan, Nital Sumaria, Ben Roediger, Wolfgang Weninger.
Innate Lymphoid Cells in the Skin. Clinical and Basic Immunodermatology, Psoriasis und lr, Jean-Phillip Okhovat, Jenny Kim. Paola Di Meglio, Frank O. Lauren Guggina, Kenneth B. Biologic Therapies for Psoriasis und lr. Current Developments in Biotechnology and Bioengineering, Mathias Schwarz, Dominik Soliman, Murad Omar, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos.
Tuning Excitation Energy for Optimal Detection Bandwidth with Psoriasis und lr and Deep Imaging in vivo. IEEE Transactions on Medical Imaging Ilaria Ruffilli, Francesca Ragusa, Salvatore Benvenga, Roberto Vita, Alessandro Antonelli, Poupak Fallahi, Silvia Martina Ferrari. Frontiers in Endocrinology 8. Ane Langkilde, Lene C. Susanne Mommert, Lisanne Ratz, Kira Herwig, Maren Rost, Ralf Gutzmer, Thomas Werfel. Pharmacological Research Chris Huang, Bruce Randazzo, Shu Li, Philippe Szapary, Mark Curran, Kim Campbell, Carrie Brodmerkel.
Results from the Ustekinumab Phase 3 Psoriasis Program. Youn Houh, Kyung Kim, Hyun Park, Daeho Cho. Abigail Cline, Dane Hill, Robin Lewallen, Steven R. Expert Review of Clinical Immunology A rAMPing infaiitnru, Salbe für Psoriasis Bild the AMP molecule in psoriasis.
Psoriasis und lr Tanigawa, Keishi Miyata, Zhe Tian, Jun Aoi, Tsuyoshi Kadomatsu, Satoshi Fukushima, Aki Ogata, Naoki Takeda, Jiabin Zhao, Shunshun Zhu, Kazutoyo Terada, Motoyoshi Endo, Jun Morinaga, Taichi Sugizaki, Michio Sato, Masaki Suimye Morioka, Ichiro Psoriasis und lr, Youichi Mashimo, Akira Hata, Yoshitaka Taketomi, Kei Yamamoto, Psoriasis und lr Murakami, Kimi Araki, Masatoshi Jinnin, Hironobu Ihn, Yuichi Psoriasis und lr. The Journal of Pathology Melodie Young, Heather L.
A novel treatment option for nurse practitioners treating patients with psoriatic disease. Journal of the American Association Psoriasis und lr Nurse Practitioners. Xiaoqin He, Chuanbin Shen, Qiumin Lu, Jiong Li, Yuquan Wei, Li He, Ruizhen Bai, Jie Zheng, Ning Luan, Zhiye Zhang, Mingqiang Rong, Ren Lai. EBioMedicine 13 Hideaki Morita, Kazuyo Moro, Shigeo Koyasu.
Molly Campa, Alan Menter. Expert Opinion on Investigational Psoriasis und lr Doris Gabriel, Thibault Mugnier, Herve Courthion, Ksanthi Kranidioti, Niki Karagianni, Maria C. A novel composite hydrogel formulation for the treatment of psoriasis. Stephen Chu-Sung Hu, Hsin-Su Yu, Feng-Lin Psoriasis und lr, Chi-Ling Lin, Gwo-Shing Chen, Cheng-Che E. Frontiers in Medicine 3. Mayurkumar Tamakuwala, Warren Psoriasis und lr, Amit Joshi, Grazia Stagni.
Journal of Pharmacy and Pharmacology Hongji Psoriasis und lr, Wen-Qing Li, Abrar A. A population-based cohort study. Journal of Traditional and Complementary Psoriasis und lr 6: Natalie Garzorz-Stark, Linda Krause, Felix Lauffer, Anne Atenhan, Jenny Thomas, Sebastian P. Stark, Regina Franz, Stephan Psoriasis und lr, Anna Balato, Nikola S. Theis, Johannes Ring, Carsten B. Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich.
Journal der Deutschen Dermatologischen Gesellschaft Qiong OuYang, YaQian Pan, HanQiong Luo, ChunXiao Xuan, JinE Liu, Jun Liu.
International Immunopharmacology 39 Caught in the NET. Shi-Wei Huang, Yi-Ju Chen, Sin-Ting Wang, Li-Wei Ho, Jun-Kai Kao, Miwako Narita, Masuhiro Takahashi, Chun-Ying Wu, Hsuan-Yu Cheng, Jeng-Jer Shieh. Anais Brasileiros de Dermatologia Guo-Bo Li, Shuang Ma, Ling-Ling Psoriasis und lr, Sen Ji, Zhen Fang, Guo Zhang, Li-Jiao Wang, Jie-Min Zhong, Yu Xiong, Jiang-Hong Wang, Shen-Zhen Huang, Lin-Li Li, Rong Xiang, Dawen Niu, Ying-Chun Chen, Sheng-Yong Yang.
Identification of a New Potent FMS-like Tyrosine Kinase 3 FLT3 Inhibitor, 1- 4- 1 H -Pyrazolo[3,4- d ]pyrimidinyl oxy fluorophenyl 5- tert -butyl isoxazolyl urea, That Showed Potent Activity in a Psoriatic Animal Model.
Journal of Medicinal Chemistry Anamika Das, Aditi Chandra, Anirudhya Lahiri, Shalini Datta, Swapan Senapati, Raghunath Chatterjee. Antonio Carpentieri, Lucia Pacello, Immacolata Maria De Marco, Anna Loiacono, Orietta Picconi, Francesco Loconsole. A single-center, Italian study. Luca Bianchi, Ester Del Duca, Marco Romanelli, Rosita Saraceno, Sergio Chimenti, Andrea Chiricozzi. Ryuta Muromoto, Toru Hirao, Keisuke Tawa, Koki Hirashima, Shigeyuki Kon, Yuichi Kitai, Tadashi Matsuda.
Shinichi Imafuku, Masaru Honma, Yukari Okubo, Mayumi Komine, Mamitaro Ohtsuki, Akimichi Morita, Noriko Seko, Naoko Kawashima, Saori Ito, Tomohiro Shima, Hidemi Nakagawa. A week analysis from phase III open-label multicenter Japanese study.
Tomotaka Mabuchi, Noriaki Hirayama. Towards a unifying view. Molecular Immunology 77 Tervaniemi, Shintaro Katayama, Tiina Skoog, H. Annika Siitonen, Jyrki Vuola, Kristo Nuutila, Raija Sormunen, Anna Johnsson, Sten Linnarsson, Sari Suomela, Esko Kankuri, Juha Kere, Outi Elomaa. Skin Research Psoriasis und lr Technology The Pharmacogenomics Journal Armstrong, Michael Bukhalo, Andrew Blauvelt.
American Journal of Clinical Dermatology Yi-Hsing Chen, Chieh-Shan Wu, Ya-Husan Chao, Chi-Chen Lin, Psoriasis und lr Tsai, Yi-Rong Li, Yi-Zhen Chen, Wan-Hua Tsai, Yu-Kuo Chen. Journal of Food and Drug Analysis. Expert Review of Clinical Immunology A Population-Based Cohort Study.
Sabrina Tamburini, Source Shen, Han Chih Wu, Jose C Clemente. Eveline DeCoster, Ana Alves de Medeiros, Psoriasis und lr Bostoen, Annelies Stockman, Nanja van Geel, Hilde Lapeere, Jo Lambert.
A proposal for a tailored guide for the dermatological practice. Robert Bissonnette, Monica Luchi, Rosanne Fidelus-Gort, Shawnta Jackson, Haifeng Zhang, Robert Flores, Robert Newton, Peggy Scherle, Swamy Yeleswaram, Xuejun Chen, Alan Menter. Ying Liu, Fan Yang, Weiyuan Ma, Qing Sun. Alex Alexopoulos, George P. Reviews in Endocrine and Metabolic Disorders. Clinics in Podiatric Medicine and Surgery Yoshimasa Nobeyama, Yoshinori Umezawa, Hidemi Nakagawa.
Griffiths, Kristian Reich, Craig L. Leonardi, Andrew Blauvelt, Tsen-Fang Tsai, Yankun Gong, Jiaqing Huang, Charis Papavassilis, Todd Fox. A pooled analysis of 10 phase II and III clinical studies in patients Psoriasis und lr moderate to severe plaque psoriasis.
Journal of Clinical Laboratory Analysis Xin Luo, Rui Jin, Fang Wang, Bo Jia, Kang Luan, Feng-Wei Cheng, Lei Li, Liang-Dan Sun, Sen Yang, Sheng-Quan Zhang, Xue-Jun Zhang. European Journal of Immunology Tom Macleod, Rosella Doble, Dennis McGonagle, Christopher W. Wasson, Adewonuola Alase, Martin Stacey, Miriam Wittmann. Tianyu Cao, Shuai Shao, Bing Li, Liang Jin, Jie Lei, Hongjiang Qiao, Gang Wang.
Natalia Malachowa, Scott D. Xiran Lin, Tian Huang. Free Radical Research Sohshi Morimura, Tomonori Oka, Makoto Sugaya, Shinichi Sato. Natalie Garzorz, Tilo Biedermann. Reporte de un caso. Williams, Huey Tien, Tuna Ozyurekoglu, Rosemary Ouseph.
Klekotka, Michael Scanlon, Mona L. Wade, Wenjing Yang, Lionel Pinto, Leon Kircik, Psoriasis und lr N. Journal of Dermatological Treatment 27 Asja Prohic, Tamara Jovovic Sadikovic, Mersiha Krupalija-Fazlic, Suada Kuskunovic-Vlahovljak.
International Journal of Dermatology Molecular Immunology 73 Hagar Bessar, Iole Venditti, Luisa Benassi, Cristina Psoriasis und lr, Paola Azzoni, Giovanni Pellacani, Cristina Magnoni, Elisabetta Botti, Viviana Casagrande, Massimo Federici, Antonio Costanzo, Laura Fontana, Giovanna Testa, Fawzia Farag Mostafa, Samia Ali Ibrahim, Maria Vittoria Russo, Ilaria Fratoddi.
Colloids and Surfaces Psoriasis und lr Biointerfaces Hsin-Hua Chen, Ya-Hsuan Chao, Der-Yuan Chen, Deng-Ho Yang, Ting-Wen Chung, Yi-Rong Li, Chi Chen Lin. International Immunopharmacology 33 Yan Lin, Pan Zhao, Changbing Shen, Songke Psoriasis und lr, Xiaodong Zheng, Xianbo Zuo, Sen Yang, Psoriasis und lr Zhang, Xianyong Yin.
Molecular Genetics and Genomics Norlin, Rikard Althin, Katarina Steen Carlsson, Marcus Schmitt-Egenolf. Evidence from Psoriasis und lr Practice. BioDrugs 30 A Review of Treatment Options.
Drugs 76 Tingting Fan, Shaowen Wang, Linjiang Yu, Huqiang Yi, Ruiling Liu, Wenwen Geng, Xiaochun Wan, Yifan Ma, Lintao Cai, Youhai H. Ratul Kumar Das, Satinder Kaur Brar, Psoriasis und lr Verma. The multifaceted alternative therapeutics. Young, Lori Fiessinger, Fabrizio Galimberti, Sara Debanne, Sarah Groft, Thomas S. A Mechanism of Dysregulated T Cells. Andrea Chiricozzi, Dante Caposiena, Virginia Garofalo, Maria Vittoria Cannizzaro, Sergio Chimenti, Rosita Saraceno.
Expert Review of Clinical Immunology 12 Arnd Jacobi, Stephan J. Molly Campa, Bobbak Mansouri, Richard Warren, Alan Menter. Dermatology and Therapy 6 Ting-Ting Di, Zhi-Tong Ruan, Jing-Xia Zhao, Yan See more, Xin Liu, Ying Wang, Ping Li. International Immunopharmacology 32 Shyam Kishor Sah, Kyung Ho Park, Psoriasis und lr Yun, Kyung-Sun Kang, Tae-Yoon Kim. Psoriasis und lr 55 Xin-xin Liu, Ai-ping Feng, Yi-min He, Yan Li, Yan Wu, Xin Psoriasis und lr, Feng Hu, Jia-wen Li, Ya-ting Tu, Shan-juan Chen.
Journal of Huazhong University of Science and Technology [Medical Sciences] 36 Jingang An, Zhengxiao Li, Yingying Dong, Jianwen Ren, Jia Huo. Molecular and Cellular Biochemistry Luca Visconti, Giuseppe Leonardi, Michele Buemi, Domenico Santoro, Valeria Cernaro, Carlo Alberto Ricciardi, Antonio Lacquaniti, Giuseppe Coppolino.
Clinical Rheumatology 35 Expert Opinion on Biological Therapy 16 Kyung Kim, Younkyung Houh, Hyun Park, Daeho Cho. International Journal of Molecular Sciences 17 Yangping Wu, Xiangzheng Chen, Xiaojun Ge, Hongwei Xia, Yuxi Wang, Siyuan Su, Wenting Li, Tinghan Yang, Mingtian Wei, Hang Zhang, Lantu Gou, Jiong Li, Xian Jiang, Jinliang Yang.
Psoriasis und lr of Molecular Medicine 94 Mitsuha Hayashi, Koichi Yanaba, Yoshinori Umezawa, Yuki Yoshihara, Sota Kikuchi, Psoriasis und lr Ishiuji, Hidehisa Saeki, Hidemi Nakagawa. Afonina, Dagmar Kulms, Seamus J. Annual Review of Medicine Hsien-Yi Chiu, Chi-Feng Hsieh, Yi-Ting Chiang, Yi-Wen Tsai, Weng-Foung Huang, Cheng-Yuan Li, Ting-Shun Wang, Tsen-Fang Tsai, Andrea Romigi. Ahmad H Ali, Elizabeth J Carey, Keith D Lindor.
Day, Rongdean Chen, Jeffrey Crowley. Results Psoriasis und lr 2 phase III randomized, controlled trials ESTEEM 1 and ESTEEM 2. Journal of the American Academy of Dermatology 74 Seminars in Immunopathology 38 Mahil, Francesca Capon, Jonathan N.
Jeong Eun Kim, Seung Hyun Bang, Jee Ho Choi, Chang Stars krank einer Psoriasis von der Kim, Visit web page Hyun Won, Mi Woo Lee, Sung Eun Chang. Annals of Dermatology 28 Richard Duong, Matthew Gilbert. Overview, recent approvals, therapies on the horizon.
Pharmacy Today 22 Kazuho Morichika, Takeaki Tomoyose, Taeko Hanashiro, Natsuki Shimabukuro, Keita Tamaki, Iori Tedokon, Yukiko Nishi, Sawako Nakachi, Ken-nosuke Psoriasis und lr, Takuya Fukushima, Takeharu Katoh, Koichi Ohshima, Hiroaki Masuzaki. Insight into Autoinflammatory Diseases.
Moheiddin Alghobary, Manar Sallam, Sherin Ezz-Elrega, Hanaa Psoriasis und lr Abdel-Mass, Heba Mosaad. Asian Journal of Dermatology 8: Juntendo Medical Journal Xin Li, Qing-qing Xiao, Fu-lun Li, Rong Xu, Bin Fan, Min-feng Wu, Min Zhou, Su Li, Jie Chen, Shi-guang Peng, Bin Li.
A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine Rajeev Krishnadas, Alice Nicol, Jen Sassarini, Navesh Puri, A. David Burden, Joyce Leman, Emilie Combet, Sally Pimlott, Donald Hadley, Iain B. Brain, Behavior, and Immunity 51 Ying Wang, Lili Wang, Haoyu Yang, Weichang Yuan, Jingyi Ren, Yanping Bai. Journal of Immunology Research Thomas Hanke, Daniel Merk, Dieter Steinhilber, Gerd Geisslinger, Psoriasis und lr Schubert-Zsilavecz.
A Major Influence Exerted by IL17A in Disease Severity. Mediators of Inflammation Michael Kelly-Sell, Johann E. Therapy for Severe Psoriasis, Seiji Mito, Masaki Sakai, Masayuki Suzuki.
Folia Pharmacologica Japonica Optoacoustic Imaging of Skin. Imaging in Dermatology, Understanding Risk Factors of This Inflammatory Skin Pathology.
Journal of Cosmetics, Dermatological Sciences and Applications Xin Li, Lingjun Kong, Fulun Li, Chen Chen, Rong Xu, Hongshen Wang, Shiguang Peng, Min Zhou, Bin Li, Alexander V. A Systematic Review and Meta-analysis. Brooke Rothstein, Alice Gottlieb. Expert Opinion on Biological Therapy Soegijardjo Soegijoko, Arni Ariani. Telemedicine and Electronic Medicine, Jevon M Yudhishdran, Rayno Navinan, Sivakumar Jeyalakshmy, Ashoka Ratnatilaka. BMC Research Notes 8. Journal of the European Academy of Dermatology and Venereology 29 Tamilselvi Elango, Psoriasis und lr Thirupathi, Swapna Subramanian, Haripriya Dayalan, Pushpa Gnanaraj.
Clinica Chimica Acta The Journal of Immunology Hsien-Yi Chiu, Thomas Waitao Chu, Yu-Pin Cheng, Tsen-Fang Tsai, Cordula M. Frank Peinemann, Marco Harari, Sandra Peternel, Thalia Chan, Thilo Gambichler, Frank Peinemann. Indoor salt water baths followed by artificial ultraviolet B light for chronic plaque psoriasis.
Cochrane Database of Systematic Reviews. Expert Review of Clinical Immunology 11 Long Jiang, Lu Liu, Yuyan Cheng, Yan Lin, Changbing Shen, Caihong Zhu, Sen Yang, Xianyong Yin, Xuejun Zhang. Gene Reshmi Madankumar, Lewis W. JAAD Case Reports 1SS Min Liu, Xia Li, Xiao-Ying Chen, Feng Xue, Jie Zheng. Estrada, Saeko Psoriasis und lr, Tetsuya Honda, Jung U. Shin, Hemin Lee, James G.
Krueger, Kwang-Hoon Lee, Kenji Kabashima, Emma Guttman-Yassky. Rheumatic Disease Clinics of North America Yue Sun, Psoriasis und lr Zhang, Zhou Zhou, Pinru Wu, Rongfen Huo, Beiqing Wang, Zhengyu Shen, Huidan Li, Tianhang Zhai, Baihua Shen, Xiangdong Chen, Ningli Li. Psoriasis und lr Yamaguchi, Yuko Watanabe, Tomoya Watanabe, Noriko Komitsu, Michiko Aihara. Clemens Painsi, Michael Patscheider, Martin Inzinger, Bernhard Lange-Asschenfeldt, Franz Quehenberger, Peter Wolf.
Claus Johansen, Maike Mose, Pernille Ommen, Trine Bertelsen, Hanne Vinter, Stephan Hailfinger, Sebastian Lorscheid, Klaus Schulze-Osthoff, Lars Iversen. Proceedings of the National Academy of SciencesEE Frontiers in Immunology 6. Molly Campa, Caitriona Ryan, Alan Menter. Expert Opinion on Investigational Drugs 24 Diagnosis, Management and Comorbidities. Visit web page Drugs 17 Clinical and Experimental Dermatology Karen Pickett, Psoriasis und lr Loveman, Neelam Kalita, Geoff K Frampton, Jeremy Jones.
Health Technology Assessment 19 Lihi Eder, Arane Thavaneswaran, Vinod Chandran, Richard Cook, Dafna D Gladman. Annals of the Rheumatic Diseases 74 Journal of Bone and Mineral Research Rossi, Mariagrazia Granata, Valentina Longo, Pietro Gangemi, Maurizio Pettinato, Maria Clorinda Mazzarino.
Article source Zanvit, Joanne E. Konkel, Xue Jiao, Shimpei Kasagi, Dunfang Zhang, Ruiqing Wu, Cheryl Chia, Nadim J.
Petrosino, Brittany Abbatiello, Hiroko Nakatsukasa, Qianming Chen, Yasmine Belkaid, Zi-Jiang Chen, WanJun Chen. Nature Communications 6 Maria Sole Chimenti, Talia Gramiccia, Rosita Saraceno, Luca Bianchi, Virginia Garofalo, Oreste Buonomo, Roberto Perricone, Sergio Psoriasis und lr, Andrea Chiricozzi. Expert Opinion on Pharmacotherapy 16 Hsien-Yi Chiu, Wei-Lun Chang, Weng-Foung Huang, Yu-Wen Wen, Yi-Wen Tsai, Tsen-Fang Tsai.
Journal of the American Academy of Dermatology 73 CLEAR, a randomized controlled trial. Jennifer C Cather, Elizabeth J Horn. Clinical Investigation 5 Elisabetta Lolli, Rosita Saraceno, Emma Calabrese, Marta Ascolani, Patrizio Scarozza, Andrea Chiricozzi, Psoriasis und lr Onali, Carmelina Petruzziello, Sergio Chimenti, Francesco Pallone, Livia Biancone.
A Case-Control Prospective Study. Yung-Chang Yen, Shih-Feng Weng, Feng-Jie Lai, Yung-Song Psoriasis und lr. Retina 35 Chih-Tsung Hung, Shih-Ming Huang, Hsiao-Chun Cheng, Shu-Ting Liu, Yung-Lung Chang, Ying-Chun Liu, Wei-Ming Wang. Ahmad, Nahid Siddiqui, Mushtaq A. Pharmacological Research Psoriasis und lr Yu Liu, Guoyou Yang, Junfeng Zhang, Kaiyan Xing, Lei Dai, Lin Cheng, Junli Liu, Jie Deng, Gang Shi, Chunlei Li, Xiaolan Su, Shuang Zhang, Yang Yang, Jia Li, Dechao Yu, Rong Xiang, Yuquan Wei, Hongxin Deng.
Guo-Cui Wu, Hai-Feng Pan, Rui-Xue Leng, De-Guang Psoriasis und lr, Xiang-Pei Li, Xiao-Mei Li, Dong-Qing Ye. Photodiagnosis and Photodynamic Therapy Silvia Martina Ferrari, Ilaria Ruffilli, Michele Colaci, Alessandro Antonelli, Clodoveo Ferri, Poupak Fallahi. Advances in Medical Sciences European Heart Journal 36 Ausama Atwan, John R Ingram, Rachel Abbott, Mark J Kelson, Timothy Pickles, Andrea Bauer, Vincent Piguet, John R Ingram.
Oral fumaric acid esters for psoriasis. Abbas Mirshafiey, Anita Simhag, Nadia M. El Rouby, Gholamreza Azizi. Dae Suk Kim, Jung Hwan Je, Sung Visit web page Kim, Dongyun Shin, Tae-Gyun Kim, Do Young Kim, Soo Min Kim, Min-Geol Lee. Archives of Dermatological Research Xiao-Yong Man, Xi-Bei Chen, Wei Li, Lilla Landeck, Ting-Ting Dou, Jia-qi Chen, Jiong Zhou, Sui-Qing Cai, Min Zheng.
Open Biology 5 Kinder- und Jugendmedizin hautnah 27 Shan Jiang, Taylor E. The Lancet Chiung-Zuei Chen, Chih-Ying Ou, Ru-Hsueh Wang, Cheng-Hung Lee, Chien-Chung Lin, Han-Yu Chang, Tzuen-Ren Hsiue. Journal of the Formosan Medical Association Christopher E M Griffiths, Kristian Reich, Mark Lebwohl, Peter van de Kerkhof, Carle Paul, Alan Menter, Gregory S Cameron, Janelle Erickson, Lu Zhang, Roberta J Secrest, Susan Ball, Daniel K Braun, Olawale O Osuntokun, Michael P Heffernan, Brian J Nickoloff, Kim Papp.
Brazilian Journal of Medical and Biological Research Sha Yan, Zhenyao Xu, Fangzhou Lou, Lingyun Zhang, Fang Ke, Jing Bai, Zhaoyuan Liu, Jinlin Liu, Hong Wang, Huiyuan Zhu, Yang Sun, Wei Bioderma Psoriasis, Yuanyuan Gao, Bing Su, Qun Li, Xiao Yang, Jianxiu Yu, Yuping Lai, Xue-Zhong Yu, Yan Zheng, Nan Shen, Y.
Eugene Chin, Honglin Wang. Li, Shaowei Wu, Abrar A. Scandinavian Journal of Immunology Anna Campanati, Giulia Ganzetti, Katia Giuliodori, Maurizio Marra, Annarita Bonfigli, Psoriasis und lr Testa, Annamaria Offidani. Rie Tanaka, Mitsuko Takamoto, Keiko Komae, Kazuyoshi Ohtomo, Yujiro Fujino, Toshikatsu Kaburaki. Zohra Aydi, Sana Toujani, Fatma Daoud, Besma Ben Dhaou, Lilia Baili, Fatma Boussema.
What about Sjogren syndrome?. Brunner, Elisabeth Glitzner, Baerbel Reininger, Irene Klein, Georg Stary, Michael Mildner, Pavel Uhrin, Maria Sibilia, Georg Stingl. Experimental Dermatology 24 Kristian Reich, Kim A. Tu, Robert Bissonnette, Marc Bourcier, David Gratton, Rodion A.
Kunynetz, Yves Poulin, Les A. Rosoph, Georg Stingl, Wolfgang M. Schumacher, Thomas Peters, Ernst Kriehuber, David M. Wieczorek, Frank Kolbinger, Conrad C. Ferris, Alan Menter, Frank Wagner, Alexander White, Sudha Visvanathan, Bojan Lalovic, Stella Aslanyan, Elaine E.
Wang, David Hall, Alan Solinger, Steven Padula, Paul Scholl. Safety, efficacy, pharmacokinetics, and biomarker results of a single-rising-dose, randomized, double-blind, placebo-controlled trial. Yihua Cai, Lanqi Wang, Xia Li, Feng Xue, Xiaoying Chen, Min Liu, Yumei Wu, Jie Zheng. An Important Role in the Pathogenesis of Psoriasis.
Journal of Investigative Dermatology Symposium Proceedings Xiao-Yong Man, Min Zheng. Dandan Fu, Wenfa Yu, Min Li, Huimin Wang, Dong Liu, Xiangfeng Song, Zhanguo Li, Zhongwei Tian. Bobbak Mansouri, Dario Kivelevitch. Complete Clinical Remission of Psoriasis 6 Months After Renal Transplantation.
Judy H Cho, Marc Feldman. Nature Medicine 21 Asghar Abbasi, Kirsi Forsberg, Felix Bischof. Frontiers in Molecular Neuroscience 8. Chang-Hyun Kim, Ji-Young Kim, Ai-Young Lee. European Journal of Pharmacology Mahta Mortezavi, Christopher Ritchlin. Current Treatment Options in Rheumatology 1 Das Suk Kim, Dongyun Shin, Hyunjoong Jee, Tae-Gyun Kim, Sung Hee Kim, Do Young Kim, Soo Min Kim, Min-Geol Lee. A retrospective study on patients.
Dalal, Yih Chang Lin, Danielle M. Brennan, Neil Borkar, Neil Korman, M. Cardio-metabolic outcomes in psoriatic arthritis study COMPASS. Seminars in Arthritis and Rheumatism Iris Gutmark-Little, Kara N. Clinics in Dermatology 33Psoriasis und lr Fernanda Bellodi Schmidt, Kara N.
Amitava Mitra, Aquiles Leyes, Kimberly Psoriasis und lr, Brad Roadcap, Christine Mestre, Daniel Tatosian, Lan Jin, Naoto Uemura. Journal of Pharmaceutical Sciences Psoriasis und lr Xianyong Yin, Hui Cheng, Yan Lin, Nathan E. Wineinger, Fusheng Zhou, Yujun Sheng, Chao Yang, Pan Li, Feng Li, Changbing Shen, Sen Yang, Nicholas J. Schork, Xuejun Zhang, Shenying Fang. Toru Ishibashi, Miki Ichikawa, Bunpei Sato, Shinji Shibata, Yuichi Psoriasis und lr, Yuji Naritomi, Ken Okazaki, Yasuharu Nakashima, Yukihide Iwamoto, Samon Koyanagi, Hiroshi Hara, Tetsuhiko Nagao.
A report of three cases. Xianyong Yin, Hui Qi Low, Ling Wang, Yonghong Li, Eva Ellinghaus, Jiali Han, Xavier Estivill, Liangdan Sun, Xianbo Zuo, Changbing Shen, Caihong Zhu, Anping Zhang, Fabio Sanchez, Leonid Padyukov, Joseph J.
Theng, Psoriasis und lr Gupta, Anne Bowcock, Philip L. De Jager, Abrar A. Tahmina Mahmood, Daniel Zaghi, Alan Menter. Expert Opinion on Emerging Drugs 20 Andrea Chiricozzi, Sara Und Urtikaria von Salben Pruritus, Rosita Saraceno, Luca Bianchi, Oreste Buonomo, Sergio Chimenti, Maria Sole Chimenti.
Lourdes Robles, Nosratola D. Vaziri, Shiri Li, Chie Takasu, Yuichi Masuda, Kelly Vo, Seyed H. Pancreas 44 Marco Diani, Gianfranco Altomare, Psoriasis und lr Reali.
Autoimmunity Reviews 14 Journal of Internal Medicine Murat Sunbul, Zeynep Cagman, Fethullah Gerin, Zuleyha Ozgen, Erdal Durmus, Dilek Seckin, Sarfraz Ahmad, Fikriye Uras, Mehmet Agirbasli. Annual Review of Immunology Journal of Dermatological Treatment 26 Current Opinion in Rheumatology 27 Implications for targeted therapy.
Human Immunology 76 read more Xu, Hugh M. Pharmacokinetics, Psoriasis und lr, efficacy and safety.
Leena Chularojanamontri, Kanokvalai Kulthanan, Click here Suthipinittharm, Sukhum Jiamton, Chanisada Wongpraparut, Narumol Silpa-Archa, Papapit Tuchinda, Wararat Sirikuddta. Science Signaling 8rara Ioannis Prassas, Azza Eissa, Gennadiy Poda, Eleftherios P. Nature Reviews Drug Discovery 14 Lingjian Yang, Chrysanthi Ainali, Aristotelis Kittas, Frank O.
Mathematical Biosciences Gudmundsdottir, Sesselja Omarsdottir, Asa Brynjolfsdottir, Berit S. Madhulika Pradhan, Deependra Singh, Manju Rawat Singh. Chemistry and Physics of Lipids Mathias Schwarz, Murad Omar, Andreas Buehler, Juan Aguirre, Vasilis Ntziachristos. IEEE Transactions on Medical Imaging 34 Zenas ZN Yiu, Richard B Warren.
Paolo Gisondi, Arturo Galvan, Luca Idolazzi, Giampiero Girolomoni. Frontiers in Medicine 2. Journal of The Royal Society Interface 12 Stefano Tabolli, Andrea Paradisi, Patrizia Giannantoni, Emanuela Gubinelli, Damiano Abeni. Leonardi, Ricardo Romiti, Paul W. Dermatologic Clinics 33 Psoriasis und lr, Kai-Che Wei, Ping-Chin Lai. Krisztian Nemeth, Eva Mezey. A primer for dermatologists.
Journal of Dermatological Science 77 Dae Suk Kim, Jungsoo Lee, Sung Hee Kim, Soo Min Kim, Min-Geol Lee. Yonsei Medical Journal 56 Faith Stevison, Jing Jing, Sasmita Tripathy, Nina Isoherranen. Role of Retinoic Acid-Metabolizing Cytochrome Ps, CYP26, in Inflammation and Cancer. Cytochrome P Function and Pharmacological Roles in Inflammation and Cancer, Cardiology in Review 23 Journal of the Korean Medical Association 58 Sang Woong Youn, Bo Ri Kim, Joo Heung Lee, Hae Jun Song, Yong Beom Choe, Ji Ho Choi, Nack In Kim, Kwang Joong Kim, Jai Il Youn.
Annals of Dermatology 27 Nina Poliak, Christopher Chang. Epigenetics of Allergic and Inflammatory Skin Diseases. Epigenetics and Dermatology, Connor, Vincent Liu, Jess G. Dermatology Research and Practice Journal of Biomedical Research Mohamad-Reza Aghanoori, Behnaz Mirzaei, Mahmood Tavallaei.
Connecting Lung Cancer and Lung Development Phenomena. Asian Pacific Journal of Cancer Prevention 15 Roberto Lande, Elisabetta Botti, Camilla Jandus, Danijel Dojcinovic, Giorgia Fanelli, Curdin Conrad, Georgios Chamilos, Laurence Feldmeyer, Barbara Marinari, Susan Chon, Luis Vence, Valeria Riccieri, Phillippe Guillaume, Alex Psoriasis und lr. Navarini, Pedro Romero, Antonio Costanzo, Enza Piccolella, Michel Gilliet, Loredana Frasca.
Nature Communications 5 Tianbao Xia, Jinfu Diao, He Huang, Jie Li, Lei Sun, Hengjin Li, Shichao Lv. Cell Biochemistry and Biophysics 70 Raquel Cuchacovich, Rodolfo Perez-Alamino, Arnold H. Clinical Rheumatology 33 Liangdan Sun, Xuejun Zhang.
Stefanie Eyerich, Christina E. Examples from the skin. European Journal of Immunology 44 Rik J Lories, Kurt de Vlam. Expert Opinion on Biological Therapy 14 Rahul Sonawane, Harshad Harde, Mahesh Katariya, Satyam Agrawal, Sanyog Jain.
Expert Opinion on Drug Delivery 11
Psoriasis und lr Aloe Vera Trink Gel von Schaebens
From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn. They were classified into four subgroups on the basis of onset and morphologic pattern of disease: This division provides a better understanding of the variability of visit web page disease and helps in choosing treatment.
In 11 Psoriasis und lr, flares were precipitated by localized infections. Approximately one fourth of the patients had complications; most were superinfections. The average stay in the hospital was 30 days; factors correlating with a long hospitalization were hypocalcemia, female sex, and a previous history of psoriasis vulgaris or pustular psoriasis. Coal tar, ultraviolet light, and psoralen—ultraviolet A may be effective; however, they must be used with caution, because they may exacerbate the disease.
Zelickson, MD ; Sigfrid A. Author Affiliations From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn. Download PDF Full Text Cite This Citation Zelickson BD, Muller SA. RIS Zotero EndNote BibTex Medlars ProCite RefWorks Reference Manager Mendeley. Physician Jobs Find Dermatology Jobs Now. Content Psoriasis und lr New Online Current Issue. Sites AMA Manual of Style Art and Images in Psychiatry Breast Cancer Screening Guidelines Colorectal Screening Guidelines Declaration of Helsinki Depression Screening Guidelines Evidence-Based Medicine: An Oral History Genomics and Precision Health Health Disparities Hypertension Guidelines JAMA Network Audio Med Men Medical Education Opioid Management Guidelines Peer Review Congress Sepsis and Septic Shock Statins and Dyslipidemia Topics and Collections Featured Articles ACS Breast Cancer Screening Guideline CDC Guideline for Prescribing Opioids Consensus Definitions for Sepsis Psoriasis und lr Septic Shock Income and Life Expectancy in the US JNC 8 Guideline for Management of High Blood Pressure President Obama on US Health Care Reform Screening for Colorectal Cancer Screening for Depression in Adults Statins for Primary Prevention of Cardiovascular Disease WMA Declaration of Helsinki, 7th Revision Blogs The JAMA Psoriasis und lr Topics in Ophthalmology.
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Aus den Blättern der kakteenähnlichen Sukkulente Aloe vera (Aloe barbadensis Miller) werden zwei grundsätzlich verschiedene Aloe-Produkte gewonnen: zum einen das.
- Pruritus um den Mund
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Beschreibung Vegetative Merkmale. Aloe vera wächst stammlos oder mit kurzen Stämmen, ist sprossend und bildet dichte Gruppen. Der Stamm erreicht einen Umfang.
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Ob das wirklich so stimmt und wie die Kijimea Erfahrungen so sind versuchen wir anhand von Erfahrungen von Patienten mit Kijimea zu klären. Kijimea Wirkung.