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LLY investigational medicine ixekizumab was statistically superior to etanercept and placebo on all skin clearance measures in Phase 3 studies, the company said today in disclosing top-line results from its pivotal UNCOVER studies in moderate-to-severe plaque psoriasis.

These results give us confidence that if approved, ixekizumab could make complete resolution of psoriasis possible for significantly more people," said David RicksLilly senior vice president, and president, Lilly Bio-Medicines.

Study design In the three UNCOVER studies, patients were assigned to receive either placebo or ixekizumab 80 mg every two or four weeks for 12 weeks, following a mg starting dose. In the two active comparator studies UNCOVER-2 and 3patients could be assigned to receive etanercept 50 mg twice weekly for 12 weeks.

In UNCOVER-1, responders to treatment were assigned to continue treatment on either placebo or ixekizumab 80 mg every 4 or 12 weeks for up to 60 weeks. Results Patients treated with both dosing regimens of ixekizumab had significantly greater levels of skin clearance compared to placebo sanknizhka bei Psoriasis to etanercept at the week endpoint. Skin clearance was measured by standard primary sanknizhka bei Psoriasis for psoriasis studies: For patients treated with ixekizumab either every four weeks or every two weeks, between 78 to 90 percent of patients achieved at least a 75 percent reduction in PASI score PASI 75 at 12 weeks.

Additionally, 31 to check this out percent of these patients achieved PASIor clear article source, at week For comparison, between 5 to 7 percent of patients treated with etanercept in the UNCOVER-2 and 3 studies achieved PASI Statistically significant improvements in skin clearance measures for patients treated with ixekizumab were observed as early as the first week when compared to either placebo or etanercept, and continued through sanknizhka bei Psoriasis In the UNCOVER-1 study, high levels of response were maintained through 60 weeks of treatment.

Adverse events were comparable for patients receiving ixekizumab sanknizhka bei Psoriasis the week, randomized control portion across all three studies. The overall rates and severities of adverse events observed were comparable to those for etanercept in the two active comparator trials. The most frequently reported events more than five percent across all three studies were nasopharyngitis and sanknizhka bei Psoriasis site reaction.

Most injection site reactions were mild, and most patients who experienced an injection site reaction continued treatment with ixekizumab. Lilly plans to submit full data from the UNCOVER studies for disclosure at scientific meetings and in peer-reviewed journals in The company intends to submit ixekizumab to regulatory authorities in the first half of About the UNCOVER studies Patients enrolled in the UNCOVER studies had a confirmed diagnosis of Institut für Psoriasis-Behandlung in Moskau plaque psoriasis for at least six months prior to randomization.

Additionally, at screening and at randomization they demonstrated at least 10 percent Body Surface Area BSA of psoriasis, an sPGA score of at least 3 and PASI score of at least UNCOVER-1 compared the safety and efficacy of different dosing regimens of ixekizumab to placebo after sanknizhka bei Psoriasis weeks and 60 weeks of treatment.

UNCOVER-2 and 3 evaluated different dosing regimens of ixekizumab compared to either placebo or etanercept for 12 weeks. About ixekizumab Ixekizumab is a monoclonal antibody with high affinity and specificity that binds to and neutralizes the pro-inflammatory cytokine interleukinA ILA. In sanknizhka bei Psoriasis, ILA plays a major sanknizhka bei Psoriasis in driving excess keratinocyte skin cell proliferation and activation. Ixekizumab does not bind to cytokines ILB, ILC, ILD, ILE or ILF.

Ixekizumab is administered via subcutaneous injection under the skin. Sanknizhka bei Psoriasis is also in clinical development for the treatment of psoriatic arthritis. About Moderate-to-Severe Plaque Psoriasis Psoriasis is a chronic, noncontagious autoinflammatory disease that appears on the skin.

It occurs when the immune system sends out faulty signals that speed up the growth cycle of skin cells. The most common form of psoriasis, plaque psoriasis, appears as raised, red patches covered with a silvery white buildup of dead skin cells.

Approximately 17 percent of psoriasis patients have moderate-to-severe plaque psoriasis. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today sanknizhka bei Psoriasis remain true to that mission in all our work. Across the globe, Doctor Ustekinumab Psoriasis einer employees work sanknizhka bei Psoriasis discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism.

To learn more about Lilly, please visit us at www. However, as with any pharmaceutical product, losterin Psoriasis are substantial risks and uncertainties in sanknizhka bei Psoriasis process of development and commercialization.

Lilly undertakes no duty to update forward-looking statements. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol ; The More info of Depression, Anxiety, and Suicidality in Patients With Psoriasis. Scott MacGregorjsmacgregor lilly. Close window Back to top.

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So giftig ist Nikotin. Injectable Corticosteroids Class Summary Intramuscular corticosteroids are not recommended for the management of psoriasis because of the risk of flare upon withdrawal.

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