Tropfer Psoriasis Patent DET2 - Ringannelierte pyrazolderivate Ring Anne lined pyrazole derivatives - Google Patents
Try the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents. Formulierungen und verfahren zur verminderung von hautirritationen Formulations and method of reducing skin irritations translated from German DE T2.
Zusammensetzung zur Hemmung von Hautreizung in einem menschlichen oder tierischen Subjekt, umfassend eine reizhemmende Menge von mM bis mM Zinn II -chlorid und ein topisches Vehikel. Composition for inhibiting skin irritation in a human or animal subject comprising an Tropfer Psoriasis amount of mM to mM tin II chloride and a topical vehicle. Composition according to one of the preceding claims, in which the composition is a cosmetic product. Composition according Tropfer Psoriasis one of the preceding claims in which the pH of the composition in the range of 1 to 6, more preferably is in the range A composition according to any one of claims 1 to 7, in which the composition is selected from the group consisting of topical drug products, preferably those in which said irritant ingredient capsaicin, and including antibiotic, Tropfer Psoriasis topical drug products selected from the group consisting of analgesics, contraceptives, anti-acne and anti-dandruff products wherein said irritant ingredient benzoyl peroxide is preferably.
Using tin II chloride for the manufacture of a topical medicament in which the Tropfer Psoriasis range of tin II chloride is Tropfer Psoriasis mM to mM, for the treatment or inhibition of skin irritation which is a irritant ingredient attributable to the Tropfer Psoriasis of the composition.
Using tin II chloride according to one of claims 12 or 13, wherein said skin irritation is selected from the group consisting of eye irritation, respiratory system irritation, irritation of the gastrointestinal system, Tropfer Psoriasis of the reproductive system, irritation of a mucous membrane, irritation of epidermal and irritation of the dermis. Using tin Tropfer Psoriasis chloride according to any of claims 12 to 14, wherein said topical composition comprises an amount of Feedback-Forum und Psoriasis-Behandlungen cation, which can inhibit the average skin irritation in subjects who her subject to A composition or use according to any one of the preceding claims, in which the composition is an antiperspirant or deodorant product.
A composition or use according to any one-of the preceding claims, in which the stimulation of the application of a Tropfer Psoriasis topical product is attributable and the Tropfer Psoriasis is packaged with instructions which recommend administration of the composition before, with or after administration of the topical product. A cosmetic method comprising applying the the juckende Haut ohne Hautausschläge Arzt of any of claims 1 to 11 to the skin, wherein the composition is a cosmetic product.
Technisches Gebiet Tropfer Psoriasis Field. Diese Erfindung betrifft Zusammensetzungen und Formulierungen und Verfahren zur Verwendung derselben, um Hautreizungen bei Tieren und Menschen zu inhibieren. This invention relates to compositions and formulations, and methods for using the same, to inhibit skin irritation in animals and humans.
Many substances are applied topically to the skin or mucous membranes of humans or animals hereafter "skin" applied to change the appearance of the subject to protect the subject from the environment or to a biological change in the skin or other tissue for therapeutic effecting preventive or cosmetic purposes. These substances may be referred to generically as "topical products" and include such topically applied substances as cosmetics, prescription and OTC topical medicines and a variety of other products, such as soaps and detergents.
Topical products are available in a variety of forms, including Tropfer Psoriasis, liquids, suspensions, semisolids such as creams, gels, pastes or "sticks"powders Tropfer Psoriasis finely dispersed liquids such as sprays or mists.
Other topical products include hand, face and body soaps and -detergenzien and other forms of skin cleaning products and household detergents and many other household Tropfer Psoriasis such as solvents, propellants, polishes, lubricants, adhesives, waxes and others which are either applied topically or where the body topically exposed during normal use. Die vorliegende Erfindung richtet sich teilweise auf Zusammensetzungen und Verfahren zur Inhibierung der Reizung, die mit derartigen topischen Produkten verbunden ist.
In a large number of cases included topical products chemicals that can produce an "irritation," including various inflammation symptoms or -anzeichen click applied to the skin or mucosa "skin" are applied.
The present invention is directed in part to compositions and A method for inhibiting the irritation associated with such Tropfer Psoriasis products. The occurrence, frequency and nature of the induced by a topical product irritation often varies from user to user. The severity of the receptive user irritation can range from subclinical to mild to severe. Typical symptoms of "irritation" Tropfer Psoriasis itching pruritusstinging, burning, tingling, "tightness," erythema redness or edema swelling.
Die Reizantwort kann auf der direkten Auswirkung von gewissen Chemikalien des topischen Produkts auf die Haut oder auf einer Antwort durch das Immunsystem beruhen, die gegen die Chemikalien allein oder in Kombination mit Hautkomponenten gerichtet ist z. The stimulus click here can on the direct effect of certain chemicals of the topical product based on skin, or on a response by the immune system, which is directed against the chemicals alone or in combination Tropfer Psoriasis skin components eg.
The sensation of itch is one of the most common skin problems experienced by humans and animals. Tropfer Psoriasis kann als eine Empfindung definiert werden, welche den Wunsch hervorruft, an der Stelle zu kratzen, von der die Empfindung ausgeht.
Itching can be defined as a sensation which provokes the desire to scratch the site from which emanates the Tropfer Psoriasis. Each skin contains sensory nerves which can transmit itch or other sensory impulses in response to a chemical, environmental exposure or disease processes. Although the precise population of itch producing nerves have not been identified, it is believed that the thinnest, non-myelinated nerve population, termed type C nociceptive neurons, the most important in producing the sensation is.
Mechanism Tropfer Psoriasis Management of Pruritus. Mechanism and Management of pruritus. San Francisco,S. Tropfer Psoriasis Francisco,p 1 to The sensory nerves of the skin can be regarded as a "common Endweg" for the Tropfer Psoriasis irritating conditions that are ultimately perceived as itching, Tropfer Psoriasis exposure to chemicals, environmental exposure such as those who have dry, itchy skin created and disease processes such as Tropfer Psoriasis dermatitis.
Viele chemische Substanzen sind in der Lage, Juckreiz oder andere sensorische Impulse zu erzeugen, wenn sie topisch auf der Haut aufgebracht werden.
Many chemical substances Tropfer Psoriasis able to produce, itch or other sensory impulses when topically applied to the skin. Regardless of what is the ultimate cause of the itching, Tropfer Psoriasis perceived sensation is the same and calls forth the desire to scratch. Viele Bestandteile, die in topischen Produkten verwendet werden, sind bekannte Reizmittel oder sind potentiell reizend, insbesondere bei Menschen mit "empfindlicher Haut".
Many ingredients used in topical products are known irritants or are potentially irritating, especially in people with "sensitive skin".
These lovely ingredients include fragrances, preservatives, click here, propellants and many other ingredients that might otherwise be considered inert components of the products. Additionally generate many active ingredients of topical products, including chemicals Tropfer Psoriasis may also be classified as drugs, irritation when applied to the skin.
These include, but are not limited to, such ingredients as exfoliants and skin cell renewal agents, anti-acne drugs, antiperspirant compounds, antihistamines, anti-inflammatory agents, skin protective agents, insect repellent chemicals, sunscreens and many others. If more than one chemical irritant is present, the irritating effects may be additive. Furthermore, the chemical Tropfer Psoriasis can react with each other or in the vicinity of the skin to form new chemicals which are irritating.
The vehicle in which the active drug ingredients are formulated, can produce irritation in sensitive people also, especially in the case of drugs such as topical corticosteroids.
In addition to chemicals which directly trigger skin irritation, some chemicals indirectly cause the skin to other chemicals or environmental conditions is more sensitive, which would normally cause no irritation.
Many chemicals which act as skin "exfoliants" such as retinoids eg. Exfoliants and other ingredients may also be the sensitivity of the skin to environmental conditions such as sunlight, wind, cold temperature and dry air or chemical means, such as antigens increase, or to aggravate the Tropfer Psoriasis which asd2 Therapie für Psoriasis a pre-existing skin disease attributable.
The barrier function acts so as Tropfer Psoriasis minimize absorption or passage of potentially irritating chemicals through the outer "dead" tent layer of Psoriasis Krankenhaus skin into the living skin tissue. Humidity extremes might increase irritation from topically applied products to a large extent. A very common condition due to low humidity is termed "winter itch" in which the properties of very low humidity of many cold climates especially if they are accompanied by residential space heating or a long exposure to refrigerated air from air conditioning in summer an itchy skin - particularly in the elderly - generated, which can exacerbate the irritating effects of topical products.
Normal processes such as sweating, can also increase Tropfer Psoriasis ability of irritant materials, such as antiperspirants, deodorants or sunscreens increase, to penetrate the skin through pores or glands that aggravates the irritation potential. Exposure to high dyukre Psoriasis environments or liquids on the skin can also increase the ability of potential irritants increase to penetrate the skin.
Similarly, the skin may be due to infection, abrasion caused by shaving, repeated or excessive washing or bathing, sun exposure, or other mechanical abrasion or other mechanical injury sensitized or inflamed what sensory irritation responses upon subsequent Tropfer Psoriasis of underarm Tropfer Psoriasis, aftershaves Tropfer Psoriasis other topical products Tropfer Psoriasis has.
In addition to chemical and environment causes of skin irritation, Tropfer Psoriasis people have an inherent sensitivity or Tropfer Psoriasis predisposition to skin irritation agent. For example, people with respiratory allergies tend to have excessively dry skin which facilitates increased absorption of potentially irritating chemicals.
The excessively dry skin which accompanies atopic dermatitis, for example, in patients with this condition creates a predisposition to irritation from many topically applied products. Other skin diseases and states such as allergic or non-allergic contact dermatitis, asthma including physical exertion-induced asthma, as it can be brought about suddenly by inhalation of cold or dry airrhinitis, conjunctivitis, inflammatory bowel disease, psoriasis, eczema, neuralgia by herpes, infectious diseases that are manifested for example by a strep throat or skin lesions such as candidiasis, insect bites and the like produce inherent irritation caused by the application of topical products or by exposure to chemical or environmental influences such as antigens, cold air, low humidity and the like, may be aggravated.
Viele andere Individuen zeigen eine empfindliche Haut als einen Zustand, der nicht mit einer identifizierbaren Hauterkrankung in Beziehung steht. Many other individuals exhibit sensitive skin as a condition that is not related to an identifiable skin disease. Was continue reading die genaue Ursache der Reizung ist, es sind viele Versuche unternommen worden, um das Reizungspotential von topischen Produkten durch die Identifikation von Chemikalien, welche die Tendenz aufweisen, eine Tropfer Psoriasis zu verursachen, und die Verringerung ihrer Konzentration oder die Beseitigung derselben aus den Produkten zu verringern.
Whatever the exact cause of irritation, many attempts have been Tropfer Psoriasis to the irritation potential of topical products by identifying chemicals that have the tendency to cause irritation and reducing their concentration or eliminating them from the products to decrease. Viele dieser Produkte werden Konsumenten als "hypoallergen" oder dergleichen angepriesen, um die verringerte Tropfer Psoriasis eines Produkts zu bezeichnen, bei Verbrauchern mit empfindlicher Haut eine Reizung zu verursachen.
Many of these products are consumers as "hypoallergenic" or the like advertised to refer to Tropfer Psoriasis reduced tendency of a product to create with consumers with sensitive skin irritation. Many skin including Mucosa- irritation responses, however, are not allergic origin. In any case, it is often not feasible or practical to identify or eliminate any or all lovely s chemical sespecially when the lovely s chemical s are Tropfer Psoriasis active ingredient of the product or if for Formulation - preservatives or other functional reasons are needed.
As an example, there is Tropfer Psoriasis substantial practical and Tropfer Psoriasis need in the field of exfoliants and related skin care products for a composition or method that the irritation caused by such products, reduced or prevented.
Anti- "dry skin" - or skin lightening agent. Siehe die US-Patente Nr. And 5, Mishima Psoriasis Blutegel al. Of hydroxy acids in concentrations high enough to peel, it is Tropfer Psoriasis known that there was often cause skin irritation and rashes.
The Tropfer Psoriasis of irritation is in people who have a delicate skin, even higher. Alternativ haben Yu et al. Such methods have the disadvantage reported on the ability of the resulting hydroxy acid to reduce to penetrate the skin, and so the beneficial effects particularly anti-acne or anti Dry skin "effects affect the hydroxy acid. Alternatively, have Yu et al. The effect of such formulations is, in turn, to raise the Tropfer Psoriasis of preparation to a non-lovely level.
However, the increased pH reduced acidity makes the resulting preparations this as flaking or less potent anti-wrinkle agent, which desirably have an acidity equal to pH 1 - having 4 - 6 and more preferably pH 2. Siehe Smith, oben, in Tabelle 1. See Smith, above, at Table 1. Other approaches to reducing the irritation associated with exfoliant products include the use of slow-release topical formulations such as polymer-based vehicles see, for. Example, Chess et al.
In addition, the particular formulations of Mishima before screening or skin-whitening tests were typically "neutralized" or adjusted to pH 5. More generally, it would be highly desirable to identify compounds with anti-irritant effects that would reduce the irritation caused by a wide range of otherwise safe and effective topical products, or to reduce the intrinsic irritation associated with various skin diseases and states such as atopic or other dermatitis, asthma including Tropfer Psoriasis asthma Tropfer Psoriasis, rhinitis or other respiratory inflammation, conjunctivitis, inflammatory bowel disease, eczema or psoriasis are Tropfer Psoriasis or exposure to irritating chemicals or environmental conditions such as antigens, sun, wind, cold air or extremes of humidity caused.
As explained below in more detail in the detailed description, the present invention includes the surprising discovery that the metal cations of the invention in reducing the incidence and severity Tropfer Psoriasis irritation associated with exposure to irritating chemicals or environmental conditions, are useful. Accordingly, the cations may alter the ability of skin nerve cells to depolarize or repolarize, as for example by blocking of or acting on the ion channel or pump operation s or by altering the transmembranal action potential, or the cations can be the transmission of nerve impulses from one nerve cell to another such as by suppressing neurotransmitter release act.
Allgemeine Beschreibungen der Funktion von Kanalproteinen sind in B. Pharmacology Physiology and Biophysics, Birkhauser Verlag Basel, Schweiz: General descriptions of the function of channel proteins in B. Pharmacology Physiology and Biophysics, Birkhauser Verlag Basel, Switzerland: Additionally or alternatively, the cations source the invention can act so that they have the effect of skin cells proteases or other irritation-inducing biological molecules Tropfer Psoriasis as eicosanoids and cytokines inhibit or modify, which can Tropfer Psoriasis activated Tropfer Psoriasis topical application of skin irritation fabrics otherwise, or they can change "econd messenger" function within sensory cells.
A number of Tropfer Psoriasis species, and certain metal cations in particular, have been associated with various aspects of nerve cell activity. For example, stands for Sleep polarized state of Tropfer Psoriasis typical nerve cell, the intracellular potassium concentration in Tropfer Psoriasis nerve axon in a high relationship with the extracellular potassium concentration, and the intracellular sodium concentration is low relative to the extracellular sodium concentration.
During the process Tropfer Psoriasis nerve depolarization flow potassium ions across the membrane out of the cell, and sodium ions flow through Psoriasis-Arthritis-Behandlung created by axonal membrane proteins known as "channels" in Tropfer Psoriasis cell.
Nach der Depolarisation wirken Membranproteine, die als Ionen-"Pumpen" bekannt sind, so, dass der ruhende, polarisierte Zustand der Zelle wiederhergestellt wird. After depolarization of the membrane proteins, which are known as Tropfer Psoriasis "pumps" act, Tropfer Psoriasis that the resting, polarized state of the cell is restored.
Tin, which has atomic number 50, is currently Kim, Zink-Psoriasis Squadrito as a counterion for delivery of fluoride to the teeth in the form of tin II fluoride.
Aluminium, das die Tropfer Psoriasis 13 aufweist, wird in oralen Antazida z. Aluminiumhydrochloriden, Aluminiumzirconiumhydrochloridsn oder Aluminiumchlorid verwendet.
Aluminum, Tropfer Psoriasis has the atomic number 13, in oral antacids eg. As aluminum hydroxide, aluminum carbonate, aluminum phosphate or Aluminiumaminoacetat contained in hemostatic pins potassium aluminum sulfate because of its astringent effect, and as an active ingredient of antiperspirant products eg. As aluminum hydrochlorides, Aluminiumzirconiumhydrochloridsn or Tropfer Psoriasis chloride is used.
The patent document EP-AO discloses a composition for the dentate application containing 0. Zinn II -chlorid wird als Stabilisator verwendet. Tropfer Psoriasis II chloride is used as a stabilizer. Tropfer Psoriasis patent document US-A discloses a composition for topical application comprising from 0. The patent document FR-A discloses a composition for the dentcle application which comprises 0.
It is an object of the present invention Foto Psoriasis intime provide visit web page, formulations, and methods of use which can suppress skin irritation due to chemical or environmental exposure, or due Tropfer Psoriasis tissue inflammation, -verletzung or other skin pathology.
The invention is particularly directed to prevent, reduce or eliminate the potential irritation caused by topical application of products containing other irritating ingredients, including especially cosmetics such as hydroxy acid or other exfoliant containing products, facial Abschilferungsmitteln, shaving products exposed sunscreen products, deodorants and other cosmetics as described above, as well Tropfer Psoriasis topical drug products containing irritating active ingredients or vehicles, and Tropfer Psoriasis products such as soaps, detergents, solvents and the like which are either applied topically or which the body in the use will.
Thus, the present invention meets a clear need for formulations and ingredients that prevent or decrease that is caused by topical products the potential skin irritation.
The invention is also useful for the prevention, reduction or elimination of the skin irritation caused by Tropfer Psoriasis diseases and other conditions, such as ambient exposure to irritating chemicals or Psoriasis-Behandlungen und Preise Israel such as wind, heat, cold, and extremes of Tropfer Psoriasis, including the intrinsic irritation with Tropfer Psoriasis connected to these conditions, as well as such irritation as may be exacerbated by the application of a topical product.
The chloride is dissolved or dispersed in a suitable vehicle. Investigations Psoriasis Seborrhoe to the present invention have shown that anti-irritant effects of the cation of the invention can be optimized by suitable selection of the accompanying anionic species. In the preferred embodiments, the cation of the invention in a suitable topical vehicle at a concentration of 50 to mM, and click preferably about to about mM Tropfer Psoriasis included.
The most highly preferred concentration range in many instances is from about Tropfer Psoriasis about mM, for example, if the formulation of the invention includes an irritant ingredient such as an exfoliant ingredient. In a further preferred embodiment, the cation of the invention Tropfer Psoriasis combined with a topical product formulation further comprising a potentially irritating ingredient, Tropfer Psoriasis cation being present in a total amount which is effective to reduce the irritation due to Tropfer Psoriasis irritant ingredient or eliminate.
In a Klette von Psoriasis Öl preferred embodiment, the cation of the invention is Tropfer Psoriasis with one or more anionic species, which are so selected to achieve Tropfer Psoriasis desired level of acidity or basicity in the formulated composition, and a total cation concentration effective to link reduce Tropfer Psoriasis skin irritation.
In such a particular preferred Tropfer Psoriasis, a cation of the present invention is combined with Tropfer Psoriasis hydroxy acid or other exfoliant preparation accompanied by one or more suitable anionic species such that the pH of the hydroxy acid preparation is in the range of pH 1 -6, and more preferably in the the range of pH is kept.
It is understood that, where the formulation employs an anhydrous vehicle, the acidity of the formulation is not typically could be expressible as pH, but that such acidity will manifest itself upon exposure of the formulation to the skin where water is both intracellularly and extracellularly.
Die Erfindung stellt weiter Verfahren zur Behandlung, Verringerung oder Beseitigung von Hautreizung bereit, welche die topische Aufbringung einer Tropfer Psoriasis umfasst, die eine reizhemmende wirksame Menge von einer oder mehreren kationischen Spezies der Erfindung umfasst. The invention further provides methods of treating, reducing or eliminating skin irritation ready, comprising the topical application of a formulation comprising an anti-irritant effective amount of Tropfer Psoriasis or more cationic species of the invention.
Tropfer Psoriasis cation formulation may further include one or more potentially irritating components. Alternatively, the cation formulation may be isolated and applied prior to application of another product containing a potentially irritating component, or the cation formulation may be Tropfer Psoriasis to prevent the development of irritation or to a pre-existing irritation alone, the conditions such as a skin diseasean action of a chemical irritant or environmental exposure is attributable to treat.
Beschreibung der Zeichnungen Psoriasis nonhormonal of the Drawings. Show in a test group of people who II chloride and control were treated in a lactic acid skin irritation action with mM tin.
Detaillierte Beschreibung Detailed Description. Additionally, formulations containing such cations, wherein the improvement of the stimulus in conditions where the skin is inherently hypersensitive to Tropfer Psoriasis products eg. As dry skin, "winter itch," and other inflammation or injury conditions and in improving the irritation useful due to such conditions even in the absence of other applied topical products.
The formulations are also useful Tropfer Psoriasis the treatment of non-human animal skin irritation, z. When applying a solution of the compound, which was used in Tropfer Psoriasis clinical tests described herein, the subjects reported no sensations other than those typical of sensations caused by the vehicle alone, and no lack of normal or Tropfer Psoriasis sensation s.
Formulierungen der Erfindung Formulations of Lassen sich von dem Juckreiz invention. Die reizhemmenden topischen Formulierungen der Erfindung umfassen ein topisches Vehikel, das zur Verabreichung an tierische insbesondere menschliche Haut geeignet ist, und eine Menge des Kations der Erfindung, die wirksam ist, eine existierende oder potentielle Hautreizung zu verringern, zu inhibieren oder zu beseitigen.
The anti-irritant topical formulations of the invention comprise a topical vehicle suitable for administration to animal particularly human skin, and to inhibit a lot of the cation of the invention effective to reduce Tropfer Psoriasis existing or potential skin irritation, or to eliminate it. The cation is accompanied Tropfer Psoriasis the formulation of the chloride counterion, although the cation-anion pairs as originally incorporated into the vehicle may become dissociated in the resulting formulation, or the cation of the invention can be used in the formulation with other anionic species associated, which occur in the total formulation.
In one embodiment, the anti-irritant topical formulations further comprise one or more irritant components which themselves have a skin irritation, as can symptoms associated Tropfer Psoriasis inflammation induce such. As a cosmetic or skin care product ingredient or a pharmaceutically active ingredient or drug part. The formulation contains such cation in a suitable topical vehicle at a concentration of 50 to about mM and most preferably about to about mM.
The most highly preferred concentration range in many cases to about mM, for example, if the formulation of the invention includes about an irritant ingredient such as an exfoliant ingredient. These preferred concentration ranges correspond to bioavailable forms of such Tropfer Psoriasis within Tropfer Psoriasis formulation, particularly ionizable and water-soluble forms of such cations, as opposed to insoluble or covalently-bonded forms of the cations.
So correspond, to name an example in which the vehicle has a density of 0. The expressed above preferred concentration ranges consider that a typical topical dosage about 0. Clinical investigations have shown that such preferred concentration ranges are generally effective to Tropfer Psoriasis skin irritation, and Tropfer Psoriasis readily formulated in typical topical vehicles, and do not leave any significant visible residue when applied Tropfer Psoriasis the skin.
Formulations with higher concentrations, such as saturated pastes or other forms, may also be successfully used, particularly where visible appearance is not limiting consideration as in therapeutic applications. Tropfer Psoriasis, routine clinical assessments such as those described below, can easily be used to optimize the cation concentration and to ascertain if lower or higher concentrations are appropriate for a given formulation or irritation indication.
Lotion in depends compared to liquid spray vehicles. Similarly, the amount Tropfer Psoriasis cation required to be reduced in such cases where the formulation contains a skin penetration-enhancing ingredient or other agent which increases the ability of the cations through the stratum corneum to Tropfer Psoriasis site Tropfer Psoriasis anti-irritant activity to permeate.
This latter measure of efficacy reflects the fact that the Tropfer Psoriasis see more, similar to many therapeutic products, may in some cases be effective, a part of, but not all of the susceptible population to a significant benefit.
Jedoch wird es weiter in Betracht gezogen, Tropfer Psoriasis die reizhemmende Wirkung im Allgemeinen bei einem "additiven" Niveau gehalten wird, wenn Bruchteile von verschiedenen Spezies der Kationen der Erfindung vereinigt werden, um eine vereinigte Gesamt-Kationen-Konzentration innerhalb der oben angegebenen Bereiche auszumachen.
However, it is further contemplated that the anti-irritant effect Tropfer Psoriasis is held at an "additive" level if fractional different species of the cations of the invention are combined to make up a total combined cation concentration within the ranges specified above. Tropfer Psoriasis optimale Konzentration eines Kations der Erfindung kann auch unter die oder innerhalb der oben angegebenen bevorzugten Bereiche verringert werden, wenn irgendeine andere reizhemmende Komponente zusammen mit der Kationen-Komponente der Erfindung in die Formulierung eingeschlossen wird.
The optimum concentration of a cation of the invention can also be reduced by the or within the preferred ranges given above if some other anti-irritant component is included along with the cation component of the invention in the formulation. Insbesondere wird in Betracht gezogen, dass niedrigere z.
In particular, it is contemplated that lower z. Dezemberbeschrieben ist. Other anti-irritant agents, such as steroids or non-steroidal anti-inflammatory Tropfer Psoriasis, or ingredients such as aloe vera, chamomile, a-bisabolol, Cola nitida extract, green tea extract, tea tree oil, licorice extract, allantoin, urea, caffeine or other xanthines, Tropfer Psoriasis glycyrrhizic acid and its derivatives may also be advantageously incorporated into the formulations of the invention to further irritation or to click the following article -Symptoms.
The cation of the invention is the present formulations, typically incorporated by mixing an appropriate amount of the chloride salt form of the selected cation, together with other topical components as are desired in the chosen formulation vehicle.
From the viewpoint of formulation, it is preferred that the selected salt in the formulation vehicle is sufficiently soluble to allow a coherent formulation having the desired physical and topical application characteristics.
It will be appreciated that depending on the chosen formulation vehicle, the salt form of the cation of the invention within the formulation can dissociate and in this case, with other anions also present in the formulation, associatinghttp://outdoor-frauen.de/psoriasis-prednison-bewertungen.php that the salt form associated remain substantially can.
It is also highly preferred that the salt chosen is sufficiently soluble in water, so that when applied to the skin, the Tropfer Psoriasis cation may dissociate and corresponding counteranion and can be added to the water-containing milieu of the skin.
In addition, it is clear that the particular salt selected constituent should be topically acceptable and preferably non-irritating to the user, toxic or harmful in other ways. Klinische Versuche, welche die Erfindung betreffen, http://outdoor-frauen.de/injektionen-prednisolon-psoriasis.php belegt, dass Zinn II - Chlorid Bilder Psoriasis-Symptome reizhemmendes Mittel besonders wirksam ist.
Clinical trials relating to the invention have established that tin II - chloride is particularly effective as a stimulus-inflammatory agent. Also preferred are these and other cation-anion pairs in which the anionic species is acidic because such pairs generally have higher solubility in many common topical vehicles and suitable ionization when applied to the skin. In addition, strongly acidic anion components may be useful where it is desired to maintain the pH of the resulting formulation at a relatively acidic level, as for example in the case of hydroxy-acid or other acidic exfoliant products, in which, to reduce the effect of the product folds or causing other beneficial effects can be reduced if the formulation is not relatively acidic.
In any case, however, the desired level of acidity in such cases can be achieved by mixing the formulation with a suitable acid or base if necessary is established. It Tropfer Psoriasis understood that, where the formulation employs an anhydrous vehicle, the acidity of the formulation may can not be expressed as a typical pH that but such acidity will manifest itself upon Tropfer Psoriasis of the formulation to the skin, in http://outdoor-frauen.de/fett-fett-in-psoriasis.php water both intracellularly present extracellularly.
Examples of such vehicles and vehicle components in the art are well known and are in such sources as Martindale. The choice of a suitable vehicle will depend on the particular physical form and the feed way, which is to obtain the formulation.
Iontophoresis or other electromagnetic enhanced delivery systems may also be usefully employed, for example to increase delivery to the dermis. Methoden und Materialien zur Herstellung von Formulierungen in einer Vielfalt von Formen sind auch in Anthony LL Hunting Hsg.
Methods and materials for preparing formulations in a variety of forms are also available in Anthony LL Hunting ed. Siehe beispielsweise Kapitel 7, S. Chapter 9, pp - all-purpose products " ; Chapter 10, pp Tropfer Psoriasis masks, creams, lotions ; Chapter 11, p primers, light and day creams ; Chapter 12pp emollientChapter 13, Tropfer Psoriasis facial treatment ; Chapter 14, pp hand products ; Chapter 15, pp body and skin creams and lotionsand Chapter 16, pp baby products.
Heilung für Psoriasis ist nicht hormonelle Formulierungen der Erfindungen werden am bevorzugtesten so formuliert, dass die Kationen-Komponente der Formulierung wie sie mit jeglichen begleitenden Anion-Gegenion-Komponenten auftrittnach Auftragung auf der Haut im Wesentlichen unsichtbar ist.
The formulations of the inventions are most preferably formulated such that the cation component of the formulation as with any accompanying anion counterion components occurs is, after application on the skin is substantially invisible. This is particularly true in the case of many cosmetic formulations that are applied to the face or other exposed parts of the body, although it is generally desirable that the cation and anion component is not visible, even when on unexposed body parts is applied.
It will be appreciated that in some cases, in particular for colored facial skin care products such as blushes, stain blocking agents, lipsticks and the like, the formulation is designed so that it über als den heilen ganzen Körper Psoriasis visible on the skin. In such cases, Tropfer Psoriasis is desirable that the cation component Tropfer Psoriasis is Tropfer Psoriasis, that is that they do not adversely the appearance of the overall formulation, when applied to the skin is changed.
In a further embodiment Tropfer Psoriasis the invention, the Tropfer Psoriasis cation can be formulated in a form for topical Tropfer Psoriasis administration to treat pain or irritation in Tropfer Psoriasis mouth, throat or other parts of the upper gastrointestinal system, such as those on a strep throat, thrush -Wundstellen, gum irritation or inflammation or the like based, including such irritation as is exacerbated by caustic or acidic foods, for ude von Psoriasis Behandlung lancer in case of ulcers or heartburn.
Weiter nimmt man an, dass Tropfer Psoriasis vorliegende Kation und orale Chloridsalz bei den beschriebenen Konzentrationen im Allgemeinen geschmacklos ist. Next, it is believed that the present cation and oral chloride salt is tasteless at the concentrations described in general.
Suitable forms for such oral Verbreichung Tropfer Psoriasis liquids eg. As mouth washes, gargles or spray solutionslozenges, tablets, pills and capsules. As with other topical forms described herein, the components used in such oral formulations should be including the cation saltselected so that Tropfer Psoriasis are non-toxic. Verfahren zur Herstellung oraler Formulierungen, die zur Verwendung in der vorliegenden Erfindung geeignet sind, sind in der Technik wohlbekannt.
A process for preparing oral formulations suitable for use Tropfer Psoriasis the present invention are well known in the art. Klinische Ergebnisse Clinical Results. The anti-irritant efficacy of the formulations of the present invention was tested and confirmed their results are described in the following examples in numerous clinical trials.
While these examples further blaue Lampe und Psoriasis various aspects and preferred Tropfer Psoriasis of the invention, as described herein, they are examples only and should not be regarded as limiting the scope of the invention Tropfer Psoriasis set forth in the claims. Beispiel 1 Example 1. Klinische Studien der reizhemmenden Wirkung Clinical trials of anti-irritant effect.
The experiments were conducted in a double blind, randomized, vehicle-controlled manner. Various formulations of the invention were tested in over people. The results confirm the highly reproducible anti-irritant effects of the cations and formulations of the Tropfer Psoriasis invention. The subjects were women who had been screened and have been shown to exhibit a normal or more than normal susceptibility to irritation by the tested irritant substance.
The tests were carried out in a plurality of groups each having 7 to ob in Psoriasis subjects. Die Subjekte wurden instruiert, keinerlei Make-up oder Gesichtslotionen am Tag des Tests in die Klinik zu tragen. The subjects were Tropfer Psoriasis to wear no makeup or facial lotions to the clinic on the Tropfer Psoriasis of the test. The subjects were instructed to wash their face Tropfer Psoriasis the Tropfer Psoriasis with a Ivon soap bar before applying the test solutions.
Skin Lovely lactic acid compositions were formulated in an appropriate vehicle Ob Teer behandelt Psoriasis to application to the skin of subjects.
The vast majority of the Tropfer Psoriasis was lovely composition 7. Die Testformulierung wurde auf einem umgrenzten Abschnitt der Haut des Subjekts, typisch continue reading Gesicht, Tropfer Psoriasis. The anti-irritant test formulations were mM prepared by combining measured amounts of salts of the cations of the present invention concentration with the lovely lactic acid composition.
The test formulation was applied to a circumscribed portion of the skin of the subject typically the face, applied. All test solutions Tropfer Psoriasis controls were applied in a double blind, randomized fashion using the prepared solutions, which had previously been placed in article source coded vial designated for use on either the right or the left side of the face or other test area was.
The solutions were typically applied using a cotton swab six strokes or a Schwammapplikators Tropfer Psoriasis the face and cheeks area that stretched from the centerline of the nose above the center of the cheek and from the cheek Tropfer Psoriasis down to the jaw line.
Die Auftragung Tropfer Psoriasis zuerst auf der rechten Continue reading und dann auf der linken vorgenommen. The application was made first to the right and then to the left. The following scaled Ratings were used for sensory Psoriasis Hautkrebs The symptom rating scores were treated separately for each individual and for the group as a Tropfer Psoriasis with the cation and the area treated with control cumulated.
Individuals who reported no cumulative assessment grade of at least "7" on at least one treatment area were excluded in a blinded fashion from further analysis to determine an irritation inhibitory activity with respect to the more susceptible test subjects. From a practical standpoint, the review notes "0" and "1" Tropfer Psoriasis be considered on the above scale to be highly desirable for a commercial product because such a response is not likely would result in a consumer ceasing to use a product.
Some consumers may indeed the "barely perceptible" sensations represented by a rating score of 1, as all an indication that a facial treatment skin care product especially an exfoliant works as advertised. In contrast, would irritation Assessment Tropfer Psoriasis of "2", "3" and "4" probably often check this out the effect that a consumer buys the product never again.
For example, Tropfer Psoriasis subject first feel a twinge, but moments later it might feel an itch without stinging. Subjects, the higher stimulus levels felt z. Clinical tests Tropfer Psoriasis over subjects, performed as generally described above demonstrated that the cations of the invention have significant and Tropfer Psoriasis anti-irritant effects, particularly if Tropfer Psoriasis are administered concurrently with Tropfer Psoriasis lovely combination.
The average inhibition of cumulative irritation for various cation salts at mM of the invention are Tropfer Psoriasis in the following table. Tropfer Psoriasis representative set of test results from several subject groups was performed using cation concentrations of mM, is given in the following table.
Reizhemmende Kationen-Daten Sexy retardant cation data Bemerkung: While individual responses vary somewhat, the overall efficacy of the present formulation is clear. Beispiel 2 Example 2. Additional Tropfer Psoriasis of anti-irritant activity using varying concentrations of aluminum and tin cations were conducted in order to assess the dose-response behavior of the present formulations.
The above-mentioned lactic acid irritation protocol was used, in which the anti-irritant cation components aluminum chloride or tin II chloride mM were. Reizungsinhibierungs cumulative data are listed in the tables below and are shown graphically in the figures. Beispiel 3 Example 3. Cation salts were formulated at various concentrations in various commercially available topical cosmetic products. The resulting mixtures generally click to see more changed the structure, color, consistency or other physical properties of the product and could be used as formulations to inhibit topical irritation.
Topical solution forms of tin II fluoride and aluminum chloride were prepared by Tropfer Psoriasis various amounts of the listed United Tropfer Psoriasis with Elizabeth Arden Visible Difference Refining Toner an alcohol-containing solution.
Es wurde gezeigt, dass die erzielten Konzentrationen wirksam waren, eine Hautreizung zu inhibieren. It has been shown that the concentrations achieved were effective to inhibit skin Tropfer Psoriasis. CAA1CACDED1EPA1EPA4EPB1USWOA1. Scott Gary HAHNOrel David THUESON. Cosmederm Technologies, San Diego. BiBTeXEndNoteRefMan. Beschreibung der Reizung Description of irritation.
KEINE Reizung NO irritation. LEICHTE Reizung — kaum wahrnehmbares Stechen, Brennen oder Jucken Tropfer Psoriasis irritation - Barely Tropfer Psoriasis stinging, burning or itching. MILDE Reizung — klares Brennen, Stechen oder Jucken MILD irritation - clear burning, stinging or itching. Prozent Inhibierung Percent inhibition. Zinn II -Chlorid Tin II chloride. Zinn II -fluorid Tin II fluoride.
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I am a sufferer of moderate to severe Psoriasis in my scalp and on my elbows. I have tried every prescription given and every over the counter treatment to treat my Psoriasis. Not wanting to get the Enbrel shots I looked into herbal remedies and vitamins that would help with my condition.
Although everyones body responds differently to different treatments this helped me tremendously with the itching and cleared up my elbows. I still have Psoriasis in my scalp but it is much better now.
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